Lorne M Golub Selected Research

Tetracycline (Achromycin)

1/2020	Periodontal therapeutics: Current host-modulation agents and future directions.
6/2016	Non-antibacterial tetracycline formulations: host-modulators in the treatment of periodontitis and relevant systemic diseases.
1/2014	A novel chemically modified curcumin reduces severity of experimental periodontal disease in rats: initial observations.
12/2011	Jack of all trades: pleiotropy and the application of chemically modified tetracycline-3 in sepsis and the acute respiratory distress syndrome (ARDS).
3/2010	Doxycycline [corrected] inhibits mononuclear cell-mediated connective tissue breakdown.
1/2005	Inhibition of breast cancer cell extracellular matrix degradative activity by chemically modified tetracyclines.
3/2002	Inhibition of cell proliferation, invasion, tumor growth and metastasis by an oral non-antimicrobial tetracycline analog (COL-3) in a metastatic prostate cancer model.

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Lorne M Golub Research Topics

Disease

28	Periodontitis 01/2022 - 07/2002
17	Inflammation (Inflammations) 04/2021 - 03/2004
9	Periodontal Diseases (Periodontal Disease) 04/2021 - 02/2011
9	Neoplasms (Cancer) 01/2020 - 03/2002
7	Chronic Periodontitis 01/2020 - 03/2004
7	Alveolar Bone Loss 01/2020 - 07/2002
7	Bone Resorption 01/2019 - 07/2002
4	Skin Diseases (Skin Disease) 06/2016 - 03/2010
3	Cardiovascular Diseases (Cardiovascular Disease) 04/2021 - 12/2011
3	Hyperglycemia 01/2021 - 01/2016
3	Peri-Implantitis 12/2020 - 01/2006
3	Rosacea (Acne Rosacea) 01/2014 - 01/2012
3	Neoplasm Metastasis (Metastasis) 12/2011 - 03/2002
2	Acute Coronary Syndrome 04/2021 - 04/2004
2	Lung Diseases (Lung Disease) 01/2020 - 01/2012
2	Body Weight (Weight, Body) 01/2019 - 07/2018
2	Kaposi Sarcoma (Kaposi's Sarcoma) 06/2016 - 01/2012
2	Wounds and Injuries (Trauma) 01/2016 - 01/2002
2	Prostatic Neoplasms (Prostate Cancer) 01/2013 - 03/2002
2	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 01/2012 - 12/2011
2	Metabolic Bone Diseases (Osteopenia) 12/2011 - 08/2008
2	Coronary Artery Disease (Coronary Atherosclerosis) 08/2007 - 04/2004
1	Osteoporosis 01/2021
1	Chronic Disease (Chronic Diseases) 01/2021
1	Prediabetic State (Prediabetes) 01/2021
1	COVID-19 01/2021
1	Head and Neck Neoplasms (Head and Neck Cancer) 01/2021
1	Arthritis (Polyarthritis) 01/2020
1	Lung Injury 04/2016
1	Bacterial Pneumonia 04/2016
1	Pneumonia (Pneumonitis) 04/2016
1	Virus Diseases (Viral Diseases) 10/2014
1	Sepsis (Septicemia) 12/2011
1	Pathologic Processes 12/2011
1	Periodontal Pocket (Periodontal Pockets) 02/2010
1	Gingivitis 08/2008
1	Periodontal Attachment Loss 08/2008
1	Osteitis 09/2007
1	Dental Plaque 01/2006
1	Infections 01/2006

Drug/Important Bio-Agent (IBA)

21	Doxycycline (Periostat)FDA LinkGeneric 06/2016 - 03/2002
19	Matrix Metalloproteinases (MMPs)IBA 01/2021 - 07/2002
12	CurcuminIBA 01/2022 - 01/2013
8	Biomarkers (Surrogate Marker)IBA 04/2021 - 04/2004
8	CytokinesIBA 01/2021 - 01/2006
8	1,7- bis(4- hydroxyphenyl)- 4- N- phenylaminocarbonylhepta- 1,6- dien- 3,5- dioneIBA 01/2021 - 01/2013
7	Tetracycline (Achromycin)FDA LinkGeneric 01/2020 - 03/2002
7	TetracyclinesIBA 01/2020 - 03/2002
7	Anti-Bacterial Agents (Antibiotics)IBA 01/2020 - 03/2002
7	Pharmaceutical PreparationsIBA 06/2016 - 03/2002
6	Matrix Metalloproteinase InhibitorsIBA 01/2022 - 03/2004
5	Collagenases (Collagenase)FDA Link 01/2020 - 03/2004
5	tetracycline CMT-3IBA 01/2012 - 03/2002
4	Matrix Metalloproteinase 8 (Neutrophil Collagenase)IBA 01/2021 - 08/2008
4	EndotoxinsIBA 01/2019 - 07/2002
4	EnzymesIBA 10/2014 - 01/2006
3	C-Reactive ProteinIBA 04/2021 - 08/2007
3	Streptozocin (Streptozotocin)FDA Link 01/2021 - 01/2016
3	GelatinasesIBA 01/2020 - 07/2002
3	CollagenIBA 01/2020 - 01/2002
3	LipopolysaccharidesIBA 01/2019 - 07/2018
2	p38 Mitogen-Activated Protein KinasesIBA 01/2020 - 08/2017
2	Biological ProductsIBA 01/2020 - 01/2019
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2019 - 01/2005
2	DiarylheptanoidsIBA 08/2017 - 01/2013
2	ZincIBA 01/2014 - 01/2013
2	TabletsIBA 07/2013 - 03/2011
2	HDL CholesterolIBA 07/2013 - 12/2011
2	CholesterolIBA 07/2013 - 12/2011
2	ImmunosorbentsIBA 02/2010 - 08/2008
2	Collagen Type I (Type I Collagen)IBA 02/2010 - 08/2008
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 04/2021
1	MineralsIBA 01/2021
1	Matrix Metalloproteinase 12IBA 01/2020
1	Flurbiprofen (Froben)FDA LinkGeneric 01/2020
1	Tartrate-Resistant Acid PhosphataseIBA 01/2019
1	Carboxymethylcellulose Sodium (Polycell)FDA Link 07/2018
1	Matrix Metalloproteinase 13IBA 01/2016
1	Anti-Inflammatory Agents (Anti-Inflammatories)IBA 01/2015
1	SB T-1214IBA 01/2013
1	4-methoxycarbonyl curcuminIBA 01/2013
1	Taxoids (Taxanes)IBA 01/2013
1	drotrecogin alfa activated (Xigris)FDA Link 12/2011
1	Interleukin-6 (Interleukin 6)IBA 12/2011
1	Apolipoprotein A-I (Apolipoprotein A1)IBA 12/2011
1	Serine Proteases (Serine Protease)IBA 12/2011
1	oxidized low density lipoproteinIBA 12/2011
1	Leukocyte Elastase (Neutrophil Elastase)IBA 12/2011
1	InterleukinsIBA 02/2010
1	Interleukin-1beta (Interleukin 1 beta)IBA 08/2008
1	Peptides (Polypeptides)IBA 08/2008
1	LipidsIBA 08/2007
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2006
1	MouthwashesIBA 01/2006

Therapy/Procedure

11	Therapeutics 04/2021 - 03/2002
4	Injections 01/2019 - 01/2014
3	Root Planing 06/2016 - 01/2006
2	Debridement 12/2020 - 03/2004
1	Radiotherapy 01/2021
1	Oral Administration 07/2018